Predictive value of changes in the level of carbohydrate antigen 19‐9 in patients with locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy

• DOI: 10.1111/codi.15355
• Publication Date: 2020-09-16T22:58:23Z
• Authors: Z. Zheng; X. Wang; Y. Huang; X. Lu; P. Chi
• Keywords: CA19-9; Chemoradiotherapy; Neoadjuvant Therapy

The aim of this work was to explore the predictive value changes in level carbohydrate antigen 19-9 (CA19-9) after neoadjuvant chemoradiotherapy (nCRT) and surgery patients with locally advanced rectal cancer (LARC).Patients LARC who underwent nCRT radical (between 2011 2016) were divided into three groups according pre-nCRT post-nCRT CA19-9 levels as follows: normal (normal group), elevated (normalized group) (nonnormalized group). pathological response criteria included ypCR downstaging (ypStages 0-I). Recurrence-free survival (RFS) overall (OS) analysed.A total 721 identified. group significantly associated (n = 159) 347) (P < 0.05). normalized 76) had worse RFS OS than 622) better nonnormalized 23) (5-year 47.0% vs 66.9% 81.5%, P 0.001; 5-year 75.4% 85.0%, 0.001). In multivariate analysis, ypTNM stage independent predictors OS. Moreover, for 23 levels, postoperative those 0.05).Following nCRT, are a strong prognostic marker long-term survival, they may be helpful selection prefer more conservative chemoradiotherapy.