C‐reactive protein (CRP) trajectory as a predictor of anastomotic leakage after rectal cancer resection: A multicentre cohort study

• DOI: 10.1111/codi.15963
• Publication Date: 2021-10-27T18:28:05Z
• Authors: Vincent T. Hoek; Cloë L. Sparreboom; Albert M. Wolthuis; Anand G. Menon; Gert‐Jan Kleinren...; André D'Hoore; Niels Komen; Johan F. Lange
• Keywords: Positive predicative value

This study aimed to identify whether CRP-trajectory measurement, including increase in CRP-level of 50 mg/l per day, is an accurate predictor anastomotic leakage (AL) patients undergoing resection for rectal cancer.A prospective multicentre database was used. CRP recorded on the first three postoperative days. Sensitivity, specificity, positive and negative predictive values, area under receiver operator characteristic (ROC) curve were used analyse performances measurements between day (POD) 1-2, 2-3, 1-3 any two days.A total 271 included study. AL observed 12.5% (34/271). Increase POD 1-2 had a value 0.92, specificity 0.71 sensitivity 0.57. Changes CRP-levels 2-3 associated with value, 0.89, 0.93 0.26, respectively. showed 0.94, 0.76 0.65. In addition, changes days 0.66 0.62. The ROC all ranged from 0.593-0.700.The present that lacks singularly rule out AL. Early safe discharge surgery adenocarcinoma cannot be guaranteed based this parameter. High values are mainly caused by relatively low prevalence