Distinct changes in the colonic microbiome associated with acute diverticulitis

• DOI: 10.1111/codi.16271
• Publication Date: 2022-08-11T08:59:44Z
• Authors: O’Grady MJ; Greg A. Turner; Sulit A; Frank A. Frizelle; Purcell R
• Keywords: Fusobacteria; Ruminococcus; Lachnospiraceae; Pathogenesis; Prevotella; Diverticulitis; Dysbiosis

The pathogenesis of acute diverticulitis (AD) remains incompletely understood, despite it being one the most common gastrointestinal conditions worldwide. aim this study was to investigate role colonic microbiome in AD.A prospective case-control performed, comparing AD patients with that controls, using 16S rRNA sequencing rectal swab samples.The individuals showed lower diversity than controls. There were significant compositional differences observed, a abundance commensal bacterial families and genera such as Lachnospiraceae, Ruminococcus Faecalibacterium compared there an increase several known pathogenic roles including Fusobacteria, Prevotella Paraprevotella.This is largest date examine microbiota patients, adds evidence proposed hypothesis alterations play AD.