A multicentre prospective single‐arm clinical trial to evaluate the treatment outcomes of prophylactic laparoscopic lateral pelvic lymph node dissection for advanced lower rectal cancer

• DOI: 10.1111/codi.70078
• Publication Date: 2025-04-02T09:48:55Z
• Authors: Atsushi Hamabe; Junichi Nishimura; Yozo Suzuki; Masayoshi Yasui; Masakazu Ikenaga; Tsukasa Tanida; Shinichi Yoshioka; Yoshihito Ide; Yusuke Takahashi; Hiroshi Takeyama; Takayuki Ogino; Hidekazu Takahashi; Norikatsu Miyoshi; Makoto Fujii; Yuko Ohno; Hirofumi Yamamoto; Kohei Murata; Mamoru Uemura; Yuichiro Doki; Hidetoshi Eguchi
• Keywords: Inferior mesenteric artery; External iliac artery

Abstract Aim There has been no prospective multicentre validation of the treatment outcomes minimally invasive lateral pelvic lymph node dissection for lower rectal cancer; hence, this study aimed to evaluate prophylactic laparoscopic dissection. Method Between May 2018 and August 2021, 90 patients with Stage II–III cancer were registered. The clearance range included nodes around internal iliac artery obturator nodes, while autonomic nerves generally preserved. primary outcome was incidence Grade III–IV postoperative complications at discharge. secondary surgical pathological outcomes, urinary function, sexual disease‐free survival overall survival. experience each facility surgeon requirements set maintain quality control Results Of patients, 87 analysed after exclusion ineligible patients. 30 57 cases, respectively, II III cancer, among which 17 underwent neoadjuvant chemotherapy. median operating time blood loss 472 min 55 mL, respectively. Postoperative observed in 22 (25.3%), complication five (5.7%). Eight harvested bilaterally, metastasis 14 Conclusion Prophylactic can be safely performed adequately quality‐controlled procedures.