Pleural fluid carcinoembryonic antigen as a biomarker for the discrimination of tumor‐related pleural effusion

• DOI: 10.1111/crj.12431
• Publication Date: 2015-12-10T11:55:00Z
• Authors: Huiling Li; Liyan Huang; Hailing Tang; Nanshan Zhong; Jianhang He
• Keywords: Carcinoembryonic antigen

Abstract Objectives To assess the value of tumor biomarkers in determination tumor‐related pleural effusion (PE). Cytological examination fluid has a limited sensitivity diagnosing PE. Methods Pleural and serum samples were obtained from 1137 patients PE etiology was determined by multiple diagnostic techniques. Carcinoembryonic antigen (CEA) levels measured both samples. Levels cancer (CA) 125, glucose, lactate dehydrogenase (LDH) assessed specimens. Results 601 diagnosed with tumors, while 595 tested individuals tumor‐free. Among biomarkers, CA LDH levels, CEA amounts comparable between tumor‐free ( P > 0.05). Only significantly different two groups < A cutoff 2.645 ng/mL yielded specificity 69.4% 82.2%, respectively, for detection. The area under curve 0.740 (95%CI: 0.710–0.770). Conclusion potential biomarker detection These findings provide an easy simple method clinical screening