The relation between distant metastasis and genetic change type in stage IV lung adenocarcinoma patients at diagnosis

• DOI: 10.1111/crj.13284
• Publication Date: 2020-09-27T11:25:50Z
• Authors: Sinem Ermin; Özgür Batum; Merve Saka Güvenç; Gülden Diniz; Aysu Ayrancı; Kadri Murat Erdoğan; Nur Yücel; Eylem Yıldırım; Taha Reşid Özdemir; Alev Gülşah Hacar; Filiz Güldaval; Altuğ Koç; Zekiye Aydoğdu; Günseli Balcı; Berk Özyılmaz; Hacer Akşit Yaşar; Özge Özer Kaya; Mine Gayaf; Özgür Kırbıyık; Nimet Aksel; Yaşar Bekir Kutbay; Tuba Nihal Ursavaş; Gülistan Karadeniz; Gülru Polat; Berna Kömürcüoğlu; Ali Kadri Çırak; Ufuk Yılmaz
• Keywords: 03 medical and health sciences; Lung Neoplasms; 0302 clinical medicine; Mutation; Humans; Receptor Protein-Tyrosine Kinases; Adenocarcinoma of Lung; Adenocarcinoma; Middle Aged; Retrospective Studies; 3. Good health

Abstract Introduction Brain metastasis prevalence is higher in patients with positive epidermal growth factor receptor (EGFR) mutation, anaplastic lymphoma kinase (ALK) and C‐ROS oncogene 1 (ROS‐1) fusion change lung adenocarcinoma. Objectives The purpose of our study to investigate the relation between genetic type initial distant stage IV adenocarcinoma changes. Methods was conducted January 2007 December 2018 a retrospective fashion who had cancer diagnosed as mutation (EGFR, ALK or ROS‐1) analysed. Results A total 845 were included study. median age 62 (28‐88). It determined that pleura metastases more frequent at significant level EGFR ( P = 0.032, 0.004, respectively). In change, be 0.001). Multiple significantly than single 0.02). Conclusion mutant adenocarcinoma, Additionally, multiple organ are