Analysis of clinical symptoms, radiological changes and pulmonary function data 4 months after COVID‐19

• DOI: 10.1111/crj.13403
• Publication Date: 2021-06-04T15:32:50Z
• Authors: Gonzalo Labarca; Mario Henríquez‐B...; Jaime Lastra; Daniel Enos; Faryd Llerena; Igor Cigarroa; Liliana Lamperti; Valeska Ormazabal; Carlos Ramirez; Eric Espejo; Nicole Canales; Fabiola Fuentes; Gloria Horta; Sebastian Fernand...; Estefania Nova‐La...
• Keywords: DLCO; Nasal cannula

Abstract Background Coronavirus disease 2019 (COVID‐19) ranges from asymptomatic to respiratory failure and requires invasive mechanical ventilation (IMV). Data about the sequelae after infection are scarce. The study aims describe prevalence of symptoms, pulmonary function tests (PFTs), radiological changes four months follow‐up. Methods A prospective, cross‐sectional, multicentre was performed. Patients with different illness severities were consecutively included (mild; moderate: hospitalized without IMV; severe: IMV). Clinical variables, health‐related quality life (HRQoL), PFT (spirometry, diffusing capacity lungs for carbon monoxide (DLCO)), (CT) scans chest obtained. association between risk (DLCO <80%) altered CT analysed using logistic regression adjusted confounding variables. Results 60 patients (18 mild, 17 moderate, 25 severe) included. Fatigue found in 11% 47% moderate 36% severe group. Altered DLCO (mild: 5.5%, 41%, 28%, p < .05) change HRQoL 50%, 94%, 60%), while group showed a higher (88% vs. 64%). Awake prone position (APP) high‐flow nasal cannula (HFNC) independently associated DLCO, Odds ratio (OR) 7.28 (CI, 1.10‐47.81; .05), CT, OR 9.50 1.26‐71.5; .05). Besides, prolonged time IMV 1.24 1.05‐1.46; Discussion It is common find radiology, PFT. In our series, use APP+HFNC days on an increased sequelae.