Prediction of Clinical Severity of COVID‐19 Using a Combination of Heparin‐Binding Protein, Interleukin‐6, and C‐Reactive Protein: A Retrospective Study

• DOI: 10.1111/crj.70003
• Publication Date: 2024-08-27T02:59:51Z
• Authors: Yidan Gao; Ke Zhao; Jing Liu; Xiangbo Zhang; Ling Gong; Xiang Zhou; Gongying Chen
• Keywords: Male; Adult; heparin‐binding protein; Severity of Illness Index; SARS‐CoV‐2; Diseases of the respiratory system; 03 medical and health sciences; COVID‐19; Predictive Value of Tests; Humans; Retrospective Studies; Aged; 0303 health sciences; RC705-779; Interleukin-6; SARS-CoV-2; COVID-19; Blood Proteins; Middle Aged; Prognosis; C‐reactive protein; C-Reactive Protein; interleukin‐6; Original Article; Female; Carrier Proteins; prognostic marker; Biomarkers; Antimicrobial Cationic Peptides

ABSTRACT Background Systemic inflammation stands as a pivotal factor tightly interwoven with the progression of COVID‐19. This study endeavors to elucidate significance three key inflammatory molecules, that is, heparin‐binding protein (HBP), interleukin‐6 (IL‐6), and C‐reactive (CRP), in assessing severity prognostic implications Methods The demographic, clinical, laboratory data were retrospectively collected from cohort 214 adult patients diagnosed Patients divided into two groups: nonsevere ( n = 93; 43.5%) severe 121; 56.5%). Additionally, based on their organ function, categorized nonorgan failure 137) 77) groups. levels inflammation‐related cytokines then compared among these defined Results group was characterized by higher proportion males, older age, longer hospital stays cases. cases exhibited prevalence underlying diseases failure. Statistical analysis revealed significantly elevated HBP, IL‐6, CRP group. identified independent risk factors for Furthermore, combined assessment biomarkers demonstrated superior diagnostic sensitivity (85.10%) specificity (95.70%) predicting COVID‐19 severity. A positive relationship between impaired function also observed. predictive efficiency increased (hazard ratio 3.631, log‐rank p 0.003) when or more them combinedly used. Notably, associated an mortality. Conclusions In conclusion, offers enhanced accuracy severity, failure, mortality