Low birthweight and risk of albuminuria in living kidney donors

• DOI: 10.1111/ctr.12321
• Publication Date: 2014-02-19T05:42:44Z
• Authors: Danielle Berglund; David MacDonald; Scott Jackson; Richard Spong; Naim Issa; Aleksandra Kukla; Scott Reule; Marc Weber; Arthur J. Matas; Hassan N. Ibrahim
• Keywords: Albuminuria

Abstract Low birthweight is linked to hypertension, chronic kidney disease and even end‐stage renal disease. We hypothesized that living donors born with lower may be at increased risk of albuminuria, or reduced GFR beyond what typical following uninephrectomy. Two hundred fifty‐seven who donated the University Minnesota between 1967 2005 underwent iohexol urinary albumin excretion measurements. Predictors <60 mL/min/1.73 m 2 , hypertension were examined using logistic regression. include age measurement, time since donation, BMI gender, serum creatinine level (at donation measurement), systolic diastolic blood pressure, race, birthweight. The latter was obtained through self‐report verified birth certificates family members. Older age, higher from associated . also hypertension. Birthweight not : OR =0.70, 95% CI (0.28, 1.74), p = 0.45 hypertension: =0.92, (0.46, 1.84), 0.82 but albuminuria: =0.37, (0.15, 0.92), 0.03. These data further strengthen link low potential adverse outcomes.