Association of TNF‐α, TGF‐β1, IL‐10, IL‐6, and IFN‐γ gene polymorphism with acute rejection and infection in lung transplant recipients

• DOI: 10.1111/ctr.12411
• Publication Date: 2014-06-26T19:13:00Z
• Authors: Hui‐jun Mu; Ping Xie; Jing‐yu Chen; Fei Gao; Jian Zou; Ji Zhang; Bin Zhang
• Keywords: Adult; Graft Rejection; Lung Diseases; Male; 0301 basic medicine; Adolescent; Interleukin-6; Histocompatibility Testing; Graft Survival; Middle Aged; Infections; Interleukin-10; 3. Good health; Interferon-gamma; 03 medical and health sciences; Cytokines; Humans; Female; Biomarkers; Aged; Follow-Up Studies; Glomerular Filtration Rate; Lung Transplantation

Infection and rejection are common complications faced by lung transplant recipients (LTRs) have become major impediments to long-term survival. Cytokines may play an important role in the development of these complications. In this study, we explored correlation between TNF-α (-308 A/G), TGF-β1 (+869 T/C, +915 G/C), IL-10 (-592 C/A, -819 -1082 G/A), IL-6 (-174 IFN-γ (+874 T/A) gene polymorphisms incidence acute infection. Transplant outcomes were reviewed a retrospective cohort 113 LTRs from single center December 2004 November 2012. Cytokine measured using sequence-specific primer-based PCR. HLA typing was performed for donors recipients. We found that with CC -592 genotypes had significantly decreased risk infection (p = 0.017, OR 0.177, 95% CI 0.04-0.85). However, no significant association cytokine rejection. Furthermore, data revealed occurrence strongly associated episodes (χ(2) 8.5256, p < 0.01). These results suggest possessing genotype be protected Our demonstrated is cause LTRs.