Improving monitoring after pancreas transplantation alone: fine‐tuning of an old technique

• DOI: 10.1111/ctr.12416
• Publication Date: 2014-07-03T08:19:50Z
• Authors: Michiel D. Voskuil; Shruti Mittal; Edward J. Sharples; Anil Vaidya; James Gilbert; Peter J. Friend; Rutger J. Ploeg
• Keywords: Pancreas transplantation

Abstract Graft survival after pancreas transplantation alone ( PTA ) is significantly poorer than graft simultaneous kidney SPK and particularly affected by difficulty in monitoring rejection. Exocrine bladder drainage allows assessment of function as urinary amylase UA ). However, standards for collection interpretation are not well defined. In this study, 21 bladder‐drained recipients were monitored with daily values urine creatinine (Creat) concentration from post‐transplant 10‐mL samples 24‐h collections. Clinical events documented correlated to measurements. found increase until day 15, large interpatient variability was noted (median 12 676 IU/L, range 668–60 369 IU/L). A strong correlation total production spot /Creat ratio r = 0.80, p < 0.001). showed less variation during episodes impaired renal function; therefore, baseline defined the median 15. > 25% decrease predicted 9/13 (69%) events. We conclude that individual baselines should be set once have stabilized 15 d measures reliable, patient friendly indicate potential .