Comparing transplant glomerulopathy in the absence of C4d deposition and donor‐specific antibodies to chronic antibody‐mediated rejection

• DOI: 10.1111/ctr.12433
• Publication Date: 2014-08-08T11:51:44Z
• Authors: Irina B. Torres; Maite Salcedo; Francesc Moreso; Joana Sellarés; Eva Castellá; M. Antonieta Azancot; Manel Perelló; Carme Cantarell; Daniel Serón
• Keywords: Donor-Specific Antibodies; Glomerulopathy

Abstract Introduction Transplant glomerulopathy ( TG ) is the characteristic lesion of chronic antibody‐mediated rejection AMR ). However, in some patients presents with no circulating HLA antibodies or C4d positivity. Aim Patients accomplishing criteria for were compared to isolated . and Methods We reviewed late (>6 months) graft biopsies performed between 2007 2010 (n = 75). Biopsies C4d‐negative donor‐specific antibody called 12), was defined according Banff consensus 17). evaluated by Luminex technology. Immunohistochemistry quantify infiltrating cells. Results older (52 ± 14 vs. 35 14; p 0.0048), received grafts from donors (54 16 41 18; 0.0554), displayed a lower inflammation glomerular (g‐score: 0.5 1.0 0.9; 0.0865; CD 3 positive cells/glomeruli: 1.5 2.9 4.4 4.1; 0.0147), interstitial (i‐score: 1.2 0.9 1.9 1.0; 0.0685; 45 cells/hpf: 18 11 57 68; 0.0132), peritubular capillary (ptc‐score 0.2 0.6 1.1 0.0089; 3.7 3.1 10.1 7.4; 0.0290) compartments. Fifteen lost survival significantly (p 0.0122). Conclusion Isolated associated less severe allograft better outcome than