The association between the incidence of intestinal graft‐vs‐host disease and antibiotic use after allogeneic hematopoietic stem cell transplantation

• DOI: 10.1111/ctr.13361
• Publication Date: 2018-07-28T06:18:50Z
• Authors: Daisuke Hidaka; Eiko Hayase; Souichi Shiratori; Yuta Hasegawa; Takashi Ishio; Takahiro Tateno; Kohei Okada; Hideki Goto; Junichi Sugita; Masahiro Onozawa; Masao Nakagawa; Kaoru Kahata; Tomoyuki Endo; Daigo Hashimoto; Takanori Teshima
• Keywords: Dysbiosis

Abstract Intestinal microbiota plays an important role in the regulation of allogeneic immune reaction after hematopoietic stem cell transplantation (allo‐ SCT ). graft‐vs‐host disease ( GVHD ) is one major causes mortality allo‐ and often complicated with intestinal dysbiosis. Recent studies suggest that antibiotic‐induced dysbiosis a risk factor for . We retrospectively evaluated impacts antibiotic use on incidence occurring before day 100 Among 213 patients who underwent , 200 achieving engraftment were analyzed. Antibiotics classified into carbapenem, quinolone, penicillin, cephem, glycopeptide. 128 developed acute 36 patients. Patients received significantly longer administration carbapenem glycopeptide compared to those without it periengraftment period. In multivariate analysis, greater than 7 days was associated increased However, antibiotics not poor overall survival high nonrelapse mortality. Long period may be Prospective are required validate our findings.