Nocardia infections in solid organ transplantation: Guidelines from the Infectious Diseases Community of Practice of the American Society of Transplantation

• DOI: 10.1111/ctr.13509
• Publication Date: 2019-02-28T18:11:30Z
• Authors: Alejandro Restrepo; Nina M. Clark
• Keywords: Nocardia Infections; Immunosuppression; Opportunistic infection

Abstract These updated guidelines from the Infectious Diseases Community of Practice American Society Transplantation review diagnosis, prevention, and management Nocardia infections after solid organ transplantation (SOT). have increased in last two decades, likely due to improved detection identification methods an expanding immunocompromised population. The risk developing nocardiosis varies with type transplanted immunosuppression regimen used. infection most commonly involves lung. Disseminated can occur, spread bloodstream, skin, or central nervous system. Early recognition initial appropriate treatment is important achieve good outcomes. Species antimicrobial susceptibility testing are strongly recommended, as inter‐ intraspecies patterns vary. Sulfonamide first‐line infections, combination therapy at least agents should be used initially for disseminated severe nocardiosis. Trimethoprim‐sulfamethoxazole (TMP‐SMX) prophylaxis may helpful preventing SOT.