Factors associated with early postoperative exercise tolerance after living‐donor liver transplantation

• DOI: 10.1111/ctr.14800
• Publication Date: 2022-08-22T10:10:30Z
• Authors: Yuji Yoshioka; Yohei Oshima; Koichiro Hata; Susumu Sato; Ryota Hamada; Tatsuya Sato; Toshimi Kaido; Fumiaki Munekage; Takashi Ito; Ryosuke Ikeguchi; Shinji Uemoto; Etsuro Hatano; Shuichi Matsuda
• Keywords: Univariate analysis; Prehabilitation

Physical dysfunction, including exercise intolerance, is a major factor for delayed societal reintegration patients who underwent living-donor liver transplantation (LDLT). However, what may contribute to early postoperative physical function not well known. The purpose of this study elucidate the perioperative factors affecting posttransplant intolerance.103 consecutive LDLT were enrolled, and 68 retrospectively analyzed. We examined relationship between tolerance evaluated by 6-minute walking distance (6MWD) at discharge after surgery demographic data, surgical information, preoperative function, clinical course, decline in with univariate multivariate analyses.Almost all discharged within 3 months surgery. 6MWD was 408 ± 94 m (68 [61-84]% predicted value), had low %6MWD significantly lower than high (grip strength: 29.8 8.9 kgf vs. 23.0 8.8 kgf, P < .01, knee extensor 138.9 59.4 Nm 95.2 42.1 Nm, .01). Multivariate analysis revealed that strength (standardized β = 0.35, .01) first day -0.22, .04) independently associated %6MWD.These results suggest maintaining muscle allowing mobilization might help enhance recovery facilitate patient's social LDLT.