A Multi‐Center International Analysis of Lung Transplantation Outcomes in Patients With COVID‐19

• DOI: 10.1111/ctr.15462
• Publication Date: 2024-09-24T13:00:08Z
• Authors: Mohammed Abul Kashem; Gabriel Loor; Amir Emtiazjoo; Matthew Hartwig; Dirk Van Raemdonck; Hannah Calvelli; Andres Leon Pena; Marcelo Salan‐Gomez; Huaqing Zhao; Michael Warnick; Mauricio Villavic...; Fabio Ius; Kamrouz Ghadimi; Jawad Salman; Satish Chandrashe...; Tiago Machuca; Pablo G. Sanchez; Kathirvel Subrama...; Arne Neyrinck; Stephen Huddleston; Laurens Ceulemans; Asishana Osho; Ethan D'Silva; Uma Ramamurthy; Andrew Shaffer; Nathaniel Langer; Yoshiya Toyoda
• Keywords: Male; Adult; SARS-CoV-2; COVID-19; Middle Aged; United States; Survival Rate; Europe; Treatment Outcome; Humans; Female; Registries; Lung Transplantation; Retrospective Studies; Aged

ABSTRACT Introduction Lung transplantation has become increasingly utilized in patients with COVID‐19. While several single‐center and UNOS database studies have been published on lung transplants (LTs) for end‐stage disease (ESLD) from Coronavirus 2019 (COVID‐19), there is a lack of multi‐center international data. Methods This multicenter analysis 11 high‐volume transplant centers the United States Europe. Data were collected through Multi‐Institutional ECLS Registry stratified by ESLD due to COVID‐19 versus other etiologies. Demographics clinical variables compared using Chi‐square test Fisher's exact test. Survival was assessed Kaplan‐Meier curves log‐rank propensity score matching. Results Of 1606 recipients, 46 (2.9%) transplanted 1560 (97.1%) without history Among patients, 30 (65.2%) had COVID‐19‐associated ARDS 16 (34.8%) post‐COVID‐19 fibrosis. higher allocation scores (78.0 vs. 44.4, p < 0.0001), severely limited functional status (37.0% 2.9%, preoperative ECMO usage (65.2% 5.4%, spent less time waitlist (32 137 days, 0.0001). A 30‐day survival comparable between non‐COVID‐19 before (100% 98.7%, = 0.39) after matching ( 0.15). Conclusions Patients who received LTs short‐term that Our findings support idea should be considered select