Tutorial on Monoclonal Antibody Pharmacokinetics and Its Considerations in Early Development

• DOI: 10.1111/cts.12567
• Publication Date: 2018-06-07T11:01:09Z
• Authors: Meric Ovacik; Kedan Lin
• Keywords: Drug Development; Pharmacodynamics

Abstract The tutorial introduces the readers to fundamentals of antibody pharmacokinetics (PK) in context drug development. Topics covered include an overview development, PK characteristics, and application PK/pharmacodynamics (PD) research development decision‐making. We also discuss general considerations for planning a nonclinical program describe types studies that should be performed during early monoclonal antibodies.