Prevalence and utility of pharmacokinetic data in preclinical studies of mRNA cancer vaccines

• DOI: 10.1111/cts.13586
• Publication Date: 2023-07-15T07:09:45Z
• Authors: Gillie A. Roth; Bianca Vora; Chloe Kim; Michael Wu; Denison Kuruvilla
• Keywords: Pharmacodynamics

In this brief report, we provide insights into current practices in preclinical messenger RNA (mRNA) cancer vaccine characterization. To enable a more automated and thorough survey of mRNA data the literature, implemented natural language processing to mine abstracts from PubMed followed by annotation selected articles. Through analysis identified gap literature wherein pharmacokinetic (PK) characterization is not reported vaccine-focused As result, field unable evaluate discuss cross-study PK pharmacodynamic (PD) relationships nor translation these species humans. vaccines rapidly evolving, there value expanding our understanding PK/PD how they relate