Large‐Scale Analysis of Age and Sex Effects on Corrected QT and JT Intervals: Insights From Hospital‐Based Controls and Moxifloxacin‐Treated Cases

• DOI: 10.1111/cts.70263
• Publication Date: 2025-06-01T16:09:09Z
• Authors: Eunwoo Kim; Hyun Young Lee; Young‐Min Ye; Anhye Kim
• Keywords: Prolongation; Clinical Significance

ABSTRACT The corrected QT (QTc) interval is a critical marker for assessing proarrhythmic potential in drug development, while the JT (JTc) provides specific insight into ventricular repolarization. This study quantitatively analyzed relationships of QTc and JTc intervals with age sex utilizing large real‐world dataset hospital‐based controls moxifloxacin‐treated patients. retrospective 1,039,550 electrocardiograms associated clinical data extracted from previously constructed electrocardiogram database, categorizing cases as ( n = 119,882) or 1586) based on predefined criteria. We observed general trend prolongation both groups, showing longer than controls. Multiple linear regression analysis indicated that controls, increased age, males exhibiting shorter females. Meanwhile, cases, showed similar age‐dependent increases, although no significant differences were interval. Therefore, this quantified effects highlighted age‐related trends underscoring relevance key factors interpreting across diverse contexts.