Primary cutaneous anaplastic large cell lymphoma with intralymphatic involvement associated with chronic lymphedema

• DOI: 10.1111/cup.12933
• Publication Date: 2017-03-24T11:28:33Z
• Authors: Peiyuan Fan; Lin Nong; Jingru Sun; Xiaoqing Liu; Marshall E. Kadin; Ting Li; Ping Tu; Yang Wang
• Keywords: Anaplastic large-cell lymphoma

Chronic lymphedema predisposes to develop malignant cutaneous tumors, including angiosarcoma, Kaposi's sarcoma and B‐cell lymphoma. T‐cell malignancy has rarely been associated with chronic lymph stasis. Here, we report a case of primary anaplastic large cell lymphoma ( pcALCL ) lymphatic spread lymphedema. The patient is 56‐year‐old man who received orchiectomy right inguinal lymphadenectomy for seminoma 10 years ago, which led prominent the leg. He developed extensive skin nodules on lymphedematous area 3 months. Histopathology findings confirmed diagnosis , subtype characterized by presence CD30 + T cells. Intralymphatic infiltration cells prominent. pathogenesis intralymphatic largely unknown. Our suggests that resulted in persistent CD4 inflammation, then may contribute development .