Clinical and histopathological spectrum of delayed adverse cutaneous reactions following COVID‐19 vaccination

• DOI: 10.1111/cup.14104
• Publication Date: 2021-07-22T15:25:47Z
• Authors: Valerie Larson; Roy Seidenberg; Avrom Caplan; Nooshin K. Brinster; Shane A. Meehan; Randie H. Kim
• Keywords: Spongiosis; Palpable purpura; Skin biopsy; Dermatopathology; Toxic Epidermal Necrolysis; Histopathology

As more people become vaccinated against the SARS-CoV-2 virus, reports of delayed cutaneous hypersensitivity reactions are beginning to emerge.In this IRB-approved retrospective case series, biopsy specimens potential adverse from Pfizer-BioNTech or Moderna mRNA vaccine were identified and reviewed. Clinical information was obtained through requisition form, referring clinician, medical chart review.Twelve cases included. Histopathological features two injection-site showed a mixed-cell infiltrate with eosinophils spongiotic dermatitis eosinophils. Three came generalized eruptions that interface changes consistent an exanthematous drug reaction. revealed predominantly pattern, eczematous dermatitis. Small-vessel vascular injury seen in specimens, which diagnosed as urticarial vasculitis leukocytoclastic vasculitis, respectively. There new-onset bullous pemphigoid supported by histopathological examination direct immunofluorescence studies. Eosinophils 10 cases.Dermatopathologists should be aware mRNA-based COVID-19 vaccines. patterns include infiltrates, epidermal spongiosis, changes. common finding but not always present. Direct studies may helpful for immune-mediated presentations such pemphigoid.