Bacteriological pathogen spectrum of chronic leg ulcers: Results of a multicenter trial in dermatologic wound care centers differentiated by regions

• DOI: 10.1111/ddg.12170
• Publication Date: 2013-08-15T16:43:42Z
• Authors: Finja Jockenhöfer; Harald Gollnick; Katharina Herberger; Georg Isbary; Regina Renner; Markus Stücker; Eva Valesky; Uwe Wollina; Michael Weichenthal; Sigrid Karrer; Joachim Klode; Joachim Dissemond
• Keywords: Male; Wound Healing; 0303 health sciences; Bacteria; Climate; Leg Ulcer; Medizin; 3. Good health; 03 medical and health sciences; Risk Factors; Germany; Health Care Surveys; Chronic Disease; Prevalence; Humans; Female; Water Microbiology; Aged

SummaryBackgroundIn almost every chronic wound different bacteria species can be detected.Patients and methodsRetrospective, multicenter evaluation of bacterial swab results from 2010 and 2011 in patients with chronic leg ulcer treated in 10 dermatologic wound care centers from 5 regions in Germany.ResultsData of 970 patients were analyzed. Staphylococcus aureus was detected in 47.6 % of the patients, 8.6% of these were methicillin‐resistant (MRSA). Pseudomonas aeruginosa was found in 31.1 %, enterobacteria in 28.6 % and Proteus mirabilis in 13.7 % of the patients. The regional comparison showed a significant south‐north gradient for S. aureus, P. aeruginosa, and enterobacteria. Moreover, a highly significant west‐east gradient for MRSA was found with detection rates of 13.5 % in the west to 4.0 % in the east. Furthermore, nationally there was a significant negative correlation between S. aureus and P. aeruginosa or P. mirabilis, respectively, as well as a positive correlation of P. aeruginosa with respect to wound size and duration. In addition to climatic and therapeutic conditions, different regional health care structures are discussed as potentially relevant reasons for these significantly different regional detection rates.ConclusionsOur data show the regional variability of the spectrum of currently detected bacteria in patients with chronic leg ulcers in Germany.