Optimal injection solution for endoscopic submucosal dissection: A randomized controlled trial of Western solutions in a porcine model

• DOI: 10.1111/den.12993
• Publication Date: 2017-11-28T04:03:22Z
• Authors: Neal Mehta; Andrew T. Strong; Matheus Franco; Tyler Stevens; Prabhleen Chahal; Sunguk Jang; Rocio Lopez; Deepa Patil; Seichiiro Abe; Yutaka Saito; Toshio Uraoka; John Vargo; Amit Bhatt
• Keywords: Endoscopic submucosal dissection

When carrying out endoscopic submucosal dissection (ESD), procedural safety increases with greater tissue elevation and efficiency longer-lasting cushion. Fluids specifically developed for ESD in Asia are not commercially available the West, leaving endoscopists to use a variety of injectable fluids off-label. To determine optimal fluid we compared commonly used Western ESD.All phases were carried an ex vivo porcine stomach model. Phase 1 duration cushions produced by various standard volumes solutions ESD. The two best-performing off-label tested head-to-head 2. 3 best solution from 2 Eleview® , currently only injection approved USA. In Phases 3, five each solution. randomized endoscopist blinded solution.The 0.4% hyaluronic acid, 6% hydroxyethyl starch (HES), . HES hydroxypropyl methylcellulose (HPMC), showing that was easier (P = 0.007), faster 0.041) required less volume 0.003). resection speed, ease total per area resected comparable between .Of