Complete clearance of painless pancreatic stones with endotherapy prevents the progression of pancreatic parenchyma atrophy in patients with chronic pancreatitis: Multicenter cohort study

• DOI: 10.1111/den.14998
• Publication Date: 2025-03-11T13:12:55Z
• Authors: Tsukasa Ikeura; Ayaka Takaori; Kazuhiro Kikuta; Ken Ito; Tetsuya Takikawa; Takaaki Eguchi; Tadahisa Inoue; Yasuki Hori; Kenji Nakamura; Mamoru Takenaka; Yoshio Sogame; Tadayuki Takagi; Nao Fujimori; Satoshi Yamamoto; Akira Nakamura; Toshitaka Sakai; Arata Sakai; Takashi Tamura; Tomotaka Saito; Koichi Fujita; Atsushi Kanno; Kunihiro Hosono; Keisuke Iwata; Atsushi Irisawa; Kazuhisa Okamoto; Masaki Kuwatani; Makoto Naganuma; Atsushi Masamune; Yoshifumi Takeyama
• Keywords: Parenchyma; Pancreatitis, chronic

Objectives This retrospective multicenter study aimed to clarify the clinical impact of endotherapy for painless pancreatic duct (PD) stones compared with that in patients who received conservative treatment without endotherapy. Methods We enrolled 268 suffering from chronic pancreatitis PD (145 and 123 endotherapy) evaluated on radiological outcomes. Results When was set as a reference, complete clearance targeted decreased relative risk atrophy parenchyma after inclusion (hazard ratio [HR] 0.42; 95% confidence interval [CI] 0.21–0.84). Incomplete identified factor new‐onset or worsening diabetes (HR 2.08; CI 1.10–3.91) inducement pain attack 4.03; 1.45–11.19), although not correlated these Conclusion In stones, stone allows maintenance parenchymal volume. However, if fails, could lead aggravation glucose tolerance attacks during follow‐up.