Cytokine dysregulation in children with cerebral palsy

• DOI: 10.1111/dmcn.14724
• Publication Date: 2020-11-13T11:24:17Z
• Authors: Zunera Zareen; Tammy Strickland; Lida Fallah; Victoria McEneaney; Lynne Kelly; Denise McDonald; Eleanor J Molloy
• Keywords: Proinflammatory cytokine

Aim To examine pro‐ and anti‐inflammatory cytokines in children with cerebral palsy (CP) at baseline response to endotoxin (lipopolysaccharide), correlate outcomes compared age‐matched comparisons, evaluate their ability mount an immune response. Method Serum were assessed 12 (eight males, four females; mean age 10y 1mo [SD 1y 8mo], 6–16y) CP against comparisons 9y 1mo]). Pro‐ (interleukin‐1β, interleukin‐2, interleukin‐6, interleukin‐8, interleukin‐10, interleukin‐18, tumour necrosis factor [TNF]‐α, TNF‐β, interferon‐γ, granulocyte‐macrophage colony‐stimulating [GM‐CSF], vascular endothelial growth [VEGF], erythropoietin, interleukin‐1 receptor antagonist) measured vitro simulation lipopolysaccharide by multiplex enzyme‐linked immunosorbent assay. Results Significantly higher erythropoietin was found the comparison group. There a strong for VEGF, TNF‐α, GM‐CSF both group; however, there significant hyporesponsiveness group interleukin‐1α, interleukin‐1β, interleukin‐6. Interpretation Altered cytokine responses demonstrate altered inflammatory state that may contribute ongoing sequelae could be target therapy. What this paper adds persist (CP). Erythropoietin is elevated Children have reduced interleukin‐6 lipopolysaccharide.