Impact of sleep, neuroendocrine, and executive function on health‐related quality of life in young people with craniopharyngioma

• DOI: 10.1111/dmcn.14866
• Publication Date: 2021-03-23T05:56:37Z
• Authors: Kristin A Niel; Kimberly L Klages; Thomas E Merchant; Merrill S Wise; Donna Hancock; Mary Caples; Belinda N Mandrell; Heather M Conklin; Valerie Mclaughli...
• Keywords: Craniopharyngioma; Executive dysfunction; Neurocognitive

To examine the impact of clinical factors, cognitive deficits, and sleepiness on health-related quality life (HRQoL) among young people with craniopharyngioma.Seventy-eight patients (67% White; 41 males, 37 females; mean age 10y 8mo, SD 3y 11mo, range 6-20y) craniopharyngioma were assessed for tumor extent diabetes insipidus. All underwent overnight polysomnography multiple sleep latency tests after surgical resection. Executive functioning was using parent-reported measures. Patients their parents completed measures HRQoL. None had a history previous radiation therapy.Path analysis used to test hypothesized relations while controlling demographic disease characteristics. Analyses revealed poorer HRQoL greater executive symptoms (estimate -0.83; p<0.001). Direct indirect effects found insipidus, functioning, Diabetes insipidus directly predicted global impairment 5.15; p=0.04) indirectly lower through -4.25; p=0.049). No significant between excessive daytime sleepiness, hypothalamic involvement, patient-reported HRQoL.These findings suggest that presenting may benefit from targeted neurocognitive psychosocial screening inform interventions. What this paper adds Children are more likely have (HRQoL). complication associated surgery, impairment.