Perinatal inflammation exposure and developmental outcomes 7 years after neonatal arterial ischaemic stroke

• DOI: 10.1111/dmcn.15522
• Publication Date: 2023-01-26T12:03:55Z
• Authors: Antoine Giraud; Mickaël Dinomais; Pauline Garel; Mathilde Chevin; Guillaume Thébault; Cyrille Renaud; Émilie Presles; Tiphaine Raia‐Barjat; Guillaume Sébire; Stéphane Chabrier
• Keywords: Male; Inflammation; Arteritis; [SDV]Life Sciences [q-bio]; Infant, Newborn; 610; Infant; 3. Good health; Brain Ischemia; 618; [SDV] Life Sciences [q-bio]; Stroke; 03 medical and health sciences; Cross-Sectional Studies; 0302 clinical medicine; Pregnancy; Humans; Female; Child; Ischemic Stroke

AbstractAimTo test the association between perinatal inflammation exposure and Full‐Scale IQ (FSIQ) score 7 years after neonatal arterial ischaemic stroke (NAIS).MethodWe conducted a cross‐sectional ancillary study nested in a multicentric longitudinal French cohort of infants born at term with NAIS between November 2003 and October 2006. Seventy‐three children were included (45 males, 28 females). The a priori defined primary outcome measure was the FSIQ score assessed with the Wechsler Intelligence Scale for Children, Fourth Edition at 7 years of age.ResultsSeventeen (23%) of the included children were exposed to perinatal inflammation. Exposure to perinatal inflammation was independently associated with an increase of FSIQ score (coefficient 13.4, 95% confidence interval 1.3–25.4; p = 0.03). Children exposed to perinatal inflammation had a higher median cerebral volume, a lower median lesion volume, and less extensive lesion distributions compared to non‐exposed children.InterpretationWe propose the existence of two NAIS categories: arteritis‐associated NAIS in children exposed to perinatal inflammation and embolism‐associated NAIS in children non‐exposed to perinatal inflammation. Identifying these two NAIS categories would open the possibility for specific curative strategies: anti‐inflammatory strategy in arteritis‐associated NAIS and recanalization strategy in embolism‐associated NAIS.