Perinatal inflammation exposure and developmental outcomes 7 years after neonatal arterial ischaemic stroke

• DOI: 10.1111/dmcn.15522
• Publication Date: 2023-01-26T12:03:55Z
• Authors: Antoine Giraud; Mickaël Dinomais; Pauline Garel; Mathilde Chevin; Guillaume Thébault; Cyrille Renaud; Émilie Presles; Tiphaine Raia‐Barjat; Guillaume Sébire; Stéphane Chabrier
• Keywords: Stroke

Abstract Aim To test the association between perinatal inflammation exposure and Full‐Scale IQ (FSIQ) score 7 years after neonatal arterial ischaemic stroke (NAIS). Method We conducted a cross‐sectional ancillary study nested in multicentric longitudinal French cohort of infants born at term with NAIS November 2003 October 2006. Seventy‐three children were included (45 males, 28 females). The priori defined primary outcome measure was FSIQ assessed Wechsler Intelligence Scale for Children, Fourth Edition age. Results Seventeen (23%) exposed to inflammation. Exposure independently associated an increase (coefficient 13.4, 95% confidence interval 1.3–25.4; p = 0.03). Children had higher median cerebral volume, lower lesion less extensive distributions compared non‐exposed children. Interpretation propose existence two categories: arteritis‐associated embolism‐associated Identifying these categories would open possibility specific curative strategies: anti‐inflammatory strategy recanalization NAIS.