The differential anti‐inflammatory effects of exercise modalities and their association with early carotid atherosclerosis progression in patients with Type 2 diabetes

• DOI: 10.1111/dme.12055
• Publication Date: 2012-10-19T05:56:13Z
• Authors: N. P. E. Kadoglou; G. Fotiadis; A. Kapelouzou; A. Kostakis; C. D. Liapis; I. S. Vrabas
• Keywords: Aerobic Exercise; Apelin

Abstract Objective Adipokines, visfatin, apelin, vaspin and ghrelin have emerged as novel cardiovascular risk factors. We aimed to evaluate the effects of different exercise modalities on aforementioned adipokines carotid intima‐media thickness in patients with Type 2 diabetes mellitus. Methods One hundred were equivalently ( n = 25) randomized into four groups: (1) a control group encouraged perform self‐controlled exercise; (2) supervised aerobic (exercise times/week, 60 min/session, 60–75% maximum heart rate); (3) resistance training (60–80% baseline load achieved one repetition); (4) combined plus group, groups 3. All participants had HbA 1c levels ≥ 48 mmol/mol (≥ 6.5%), without overt diabetic vascular complications. Blood samples, clinical characteristics, peak oxygen uptake measurements obtained at end study, after 6 months. Results At baseline, there non‐significant differences between groups. active significantly ameliorated glycaemic profile, insulin sensitivity triglycerides compared P < 0.05). Aerobic further improved lipids, systolic blood pressure capacity Moreover, high‐sensitivity C‐reactive protein visfatin decreased, while apelin circulating increased within other Within‐ between‐group comparisons showed negligible alterations serum body weight all modalities. Finally, attenuated progression (0.017 ± 0.006 mm) subjects (0.129 0.042 mm, 0.001). That effect was independently associated amelioration uptake. Conclusions In diabetes, metabolic profile. Importantly, predominantly concentrations progression.