Ultrasound detection of insulin‐induced lipohypertrophy in Type 1 and Type 2 diabetes

• DOI: 10.1111/dme.13764
• Publication Date: 2018-06-16T13:45:11Z
• Authors: J. E. Kapeluto; B. W. Paty; S. D. Chang; G. S. Meneilly
• Keywords: Vascularity; Subclinical infection; Palpation; Echogenicity

To define standard criteria for the detection of lipohypertrophy using ultrasonography and to determine accuracy this method.Individuals insulin therapy ≥2 years with unknown status were enrolled at a diabetes education centre. A team educator nurses performed clinical examination evidence separate ultrasonographers examined participants in blinded fashion.The echo signature consisted location subcutaneous layer lesions that 1) well circumscribed either by hyperechoic foci defined borders or nodular shape hypoechoic halo, 2) heterogeneous echotexture compared surrounding tissue, 3) associated distortion connective tissue 4) absence vascularity 5) capsule. Ultrasonography identified individuals significantly more frequently than inspection palpation (P<0.0001). Inter-observer agreement was moderate (κ=0.50) limited presence subclinical 73% participants.The ultrasound is consistent reproducible signature. (ClinicalTrials.gov registration no: NCT02348099).