Pancreas size and exocrine function is decreased in young children with recent‐onset Type 1 diabetes

• DOI: 10.1111/dme.13987
• Publication Date: 2019-05-16T05:53:45Z
• Authors: P. Augustine; R. Gent; J. Louise; M. Taranto; M. Penno; R. Linke; J. J. Couper
• Keywords: Subclinical infection; Exocrine pancreatic insufficiency

Abstract Aims To measure pancreatic area and exocrine function in young children with recent‐onset Type 1 diabetes to determine whether the pancreas is also affected pathophysiology of early childhood diabetes. Methods Thirty‐two (14 boys) aged 5.5 (4.5, 7.3) median ( IQR ) years presenting 90 controls (44 similar age had ultrasound imaging pancreas. Children were receiving insulin without ketosis. Transverse longitudinal areas measured by digitalized outline. Pancreatic faecal elastase‐1 was analysed using an enzyme‐linked immunosorbent assay kit 38 first‐degree relative control children. Results reduced Mean transverse SD 6.82 cm 2 (1.61) vs. 8.31 (1.74) controls, adjusted estimate (95% CI 1.45 (‐2.12, ‐0.79), P < 0.001; 1.28 (0.44) 1.55 (0.43), ‐0.27 (‐0.45, ‐0.09), = 0.003. Faecal levels 455 (323, 833) ug/g, 1408 μg/g (1031, 1989) 0.001. Conclusion accompanying subclinical very This supports changes life.