Elevated fasting vs post‐load glucose levels and pregnancy outcomes in gestational diabetes: a population‐based study

• DOI: 10.1111/dme.14173
• Publication Date: 2019-11-09T10:34:42Z
• Authors: E. A. Ryan; A. Savu; R. O. Yeung; L. E. Moore; S. L. Bowker; P. Kaul
• Keywords: Glucose tolerance test

To examine the relative association between fasting plasma glucose vs post-load (1-h and 2-h) levels based on oral tolerance test in pregnancy large-for-gestational-age hypertensive disorders of outcomes.All live singleton births October 2008 December 2014 Alberta, Canada were included. Gestational diabetes mellitus was diagnosed using Diabetes criteria. Logistic regression models used to values infants after adjusting for maternal characteristics pharmaceutical intervention gestational pregnancies.Among 257 547 pregnancies, 208 344 (80.9%) had negative 50-g challenge tests, 36 261 (14.1%) 75-g 12 942 (5.0%) either elevated (n=4130, 1.6%) or 1-h and/or 2-h (n=8812, 3.4%). Large-for-gestational-age rates 8.1% 5.1% 11.0% 7.0% 22.4% 11.9% pregnancies with glucose, 9.1% 8% levels, respectively. Among those at higher risk large-for-gestational age (adjusted odds ratio 2.66, 95% CI 2.39-2.96) 1.51, 1.33-1.72) outcomes elevations only. Fasting remained significantly associated adverse without pharmacological intervention.Elevated women is a stronger predictor than glucose.