One‐year postpartum weight retention and glucose intolerance in women with prediabetes after gestational diabetes

• DOI: 10.1111/dme.15400
• Publication Date: 2024-07-03T10:42:03Z
• Authors: Valérie Mievis; Caro Minschart; Nele Myngheer; Toon Maes; Christophe de Block; Niels Bochanen; Inge van Pottelbergh; Pascale Abrams; Wouter Vinck; Liesbeth Leuridan; Sabien Driessens; Jaak Billen; Christophe Matthys; Annouschka Laenen; Annick Bogaerts; Chantal Mathieu; Katrien Benhalima
• Keywords: Prediabetes

Abstract Aims To determine risk factors for 1‐year postpartum weight retention (PPWR) and glucose intolerance (prediabetes + diabetes) in women with a previous history of gestational diabetes (GDM) prediabetes early postpartum. Methods In this exploratory analysis the MELINDA randomized controlled trial, we report data 167 at 6–16 weeks (early) oral tolerance test after recent GDM. Results Of all participants, 45% (75) had PPWR >0 kg Compared to without PPWR, higher gain [10.5 ± 6.4 vs. 6.5 4.5 kg, p < 0.001], BMI ( 0.01) worse metabolic profile (higher waist circumference, lipid more insulin resistance) (all 0.05) both late 40.0% developed syndrome, compared 18.9% = 0.003). The only independent predictor was 0.001). 55.1% (92) (84 prediabetes, 8 Independent predictors were lower age start therapy pregnancy delivery by caesarean section (resp. 0.044 0.014). Conclusions GDM postpartum, strong while earlier during