Patient‐reported outcome results in patients with type 2 diabetes treated with once‐weekly dulaglutide: data from the AWARD phase III clinical trial programme

• DOI: 10.1111/dom.12624
• Publication Date: 2015-12-22T09:42:51Z
• Authors: M. Yu; K. Van Brunt; O. J. Varnado; K. S. Boye
• Keywords: Male; Dose-Response Relationship, Drug; Injections, Subcutaneous; Recombinant Fusion Proteins; Glucagon-Like Peptides; Middle Aged; Overweight; Drug Administration Schedule; Glucagon-Like Peptide-1 Receptor; Body Mass Index; Immunoglobulin Fc Fragments; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Diabetes Mellitus, Type 2; Double-Blind Method; Hyperglycemia; Quality of Life; Humans; Hypoglycemic Agents; Drug Therapy, Combination; Female; Aged

We evaluated patient‐reported outcome (PRO) measures from the Assessment of Weekly AdministRation of LY2189265 (dulaglutide) in Diabetes (AWARD) clinical trial programme for dulaglutide (1.5 mg and 0.75 mg) in patients with type 2 diabetes (T2D). The Impact of Weight on Self‐Perception (IW‐SP), Impact of Weight on Ability to Perform Physical Activities of Daily Living (APPADL), Impact of Weight on Quality of Life‐Lite, EQ‐5D, Diabetes Treatment Satisfaction Questionnaire (DTSQ), Diabetes Symptom Checklist‐Revised and Adult Low Blood Sugar Survey were administered and analysed for changes from baseline in one or more AWARD studies. Significant within‐group changes from baseline to the primary time point were observed for several PRO measures across all studies. Compared with insulin glargine, significantly greater improvements in the IW‐SP score were observed with dulaglutide 1.5 mg and with both dulaglutide doses in the APPADL score. Both dulaglutide doses resulted in significantly greater improvement in DTSQ scores (all subscales) compared with exenatide. Dulaglutide 1.5 mg also resulted in significantly greater improvement on the DTSQ hyperglycaemia subscale compared with metformin. Overall, these PRO results suggest that dulaglutide is beneficial in the treatment of T2D.