Glucose‐dependent insulinotropic peptide secretion is induced by inflammatory stimuli in an interleukin‐1‐dependent manner in mice

• DOI: 10.1111/dom.12711
• Publication Date: 2016-06-28T08:22:57Z
• Authors: F. Kahles; C. Meyer; S. Diebold; A. C. Foldenauer; R. Stöhr; J. Möllmann; C. Lebherz; H. M. Findeisen; N. Marx; M. Lehrke
• Keywords: Proinflammatory cytokine; Incretin

Recently, glucagon-like peptide-1 (GLP-1) levels have been found to be increased in response inflammatory stimuli, leading insulin secretion and prevention of hyperglycaemia during endotoxemia mice. In the present study, we assess relevance other incretin hormone, glucose-dependent insulinotropic peptide (GIP), as a regulator glucose metabolism under conditions. We that lipopolysaccharide (LPS) GIP time- dose-dependent manner C57BL/6J To elucidate underlying mechanisms, mice were injected with cytokines known released by LPS. Circulating significantly interleukin (IL)-1β but not IL-6 or tumour necrosis factor (TNF)-α administration. Using respective knockout LPS-mediated was selectively dependent on IL-1 signalling. evaluate functional pretreated GIP-receptor antagonist (Pro3)GIP. This blunted LPS-induced TNF-α did affect blood glucose-lowering. conclusion, provides novel link between immune system gut, proinflammatory-immune modulatory function minor regulatory context acute endotoxemia.