Prevalence of elevated liver enzymes in adults with type 1 diabetes: A multicentre analysis of the German/Austrian DPV database

• DOI: 10.1111/dom.12929
• Publication Date: 2017-03-03T04:22:40Z
• Authors: Marietta Stadler; Esther Bollow; Maria Fritsch; Wolfgang Kerner; Ingrid Schuetz‐Fu...; Dietmar Krakow; Sigrun Merger; Michaela Riedl; Peter Jehle; Reinhard W. Holl
• Keywords: Dyslipidemia; Elevated liver enzymes; Liver enzyme; Alanine aminotransferase; Subgroup analysis

Aims To assess the prevalence of elevated liver enzymes in adults with type 1 diabetes mellitus ( T1DM ) routine clinical care and association cardiovascular risk profile D iabetes‐ P rospective‐ ocumentation DPV network G ermany A ustria. Subjects methods This cross sectional observational study from registry includes data 45 519 at 478 centres up to S eptember 2016. Liver enzyme measurements were available 9226 (29%) patients 270 analysed for increased alanine aminotransferase ALT ; men >50 U/L , women > 35U / L and/or aspartate AST gamma‐glutamyltransferase GGT 60U >40 U/ ). subgroup analysis whom 2 or more (n = 2335, 25%) whose was least twice (men >30 19U /L) performed. Associations glycaemic control, factors late complications investigated multiple regression analyses. Results Twenty percent (19.8%, n 1824) had enzyme(s) on one occasions. Increased associated worse control higher BMI (both < .0001), dyslipidemia OR 1.75; 95% CI 1.54‐2.0), hypertension (OR, 1.48; CI: 1.31‐1.68), myocardial infarction 1.49; 1.17‐1.91) end stage renal disease 1.59; 1.17‐2.17). 29% 1.58; 1.26‐1.97) 1.89; 1.51‐2.37). Conclusions In this audit assessment a less favourable poorer control.