Relationship between obesity and severe COVID‐19 outcomes in patients with type 2 diabetes: Results from the CORONADO study

• DOI: 10.1111/dom.14228
• Publication Date: 2020-10-14T08:02:40Z
• Authors: Sarra Smati; Blandine Tramunt; Matthieu Wargny; Cyrielle Caussy; Bénédicte Gaborit; Camille Vatier; Bruno Vergès; Deborah Ancelle; Coralie Amadou; Leila A. Bachir; Olivier Bourron; Christine Coffin‐...; Sara Barraud; Anne Dorange; Bénédicte Fremy; Jean‐François Gau...; Natacha Germain; Etienne Larger; Stéphanie Laugier...; Laurent Meyer; Arnaud Monier; Isabelle Moura; Louis Potier; Nadia Sabbah; Dominique Seret‐B...; Patrice Winiszewski; Matthieu Pichelin; Pierre‐Jean Saulnier; Samy Hadjadj; Bertrand Cariou; Pierre Gourdy
• Keywords: Obesity paradox

Abstract Aim To assess the relationship between body mass index (BMI) classes and early COVID‐19 prognosis in inpatients with type 2 diabetes (T2D). Methods From CORONAvirus‐SARS‐CoV‐2 Diabetes Outcomes (CORONADO) study, we conducted an analysis patients T2D categorized by four BMI subgroups according to World Health Organization classification. Clinical characteristics COVID‐19–related outcomes (i.e. intubation for mechanical ventilation [IMV], death discharge day 7 [D7]) were analysed status. Results Among 1965 T2D, 434 (22.1%) normal weight (18.5‐24.9 kg/m , reference group), 726 (36.9%) overweight (25‐29.9 ) 805 (41.0%) obese subjects analysed, including 491 (25.0%) class I obesity (30‐34.9 314 (16.0%) II/III (≥35 ). In a multivariable‐adjusted model, primary outcome IMV and/or D7) was significantly associated (OR 1.65 [1.05‐2.59]), 1.93 [1.19‐3.14]) 1.98 [1.11‐3.52]). After multivariable adjustment, D7 aged younger than 75 years, while such association no longer found those older years. Conclusions Overweight are poor hospitalized COVID‐19. Importantly, deleterious impact of on observed elderly, highlighting need specific management this population.