Efficacy of 1‐hour postload plasma glucose as a suitable measurement in predicting type 2 diabetes and diabetes‐related complications: A post hoc analysis of the 30‐year follow‐up of the Da Qing IGT and Diabetes Study

• DOI: 10.1111/dom.15547
• Publication Date: 2024-03-16T06:17:58Z
• Authors: Minying Peng; Siyao He; Jinping Wang; Yali An; Xin Qian; Bo Zhang; Lihong Zhang; Bo Chen; Zhiwei Yang; Guangwei Li; Qiuhong Gong
• Keywords: Post-hoc analysis

Abstract Aim To evaluate whether 1‐hour plasma glucose (1hPG) can be a comparable measurement to 2‐hour (2hPG) in identifying individuals at high risk of developing diabetes. Methods A total 1026 non‐diabetic subjects the Da Qing IGT and Diabetes Study were included classified according baseline postload 1hPG. The participants followed up assessed 6‐, 20‐ 30year follow‐up for outcomes including diabetes, all‐cause cardiovascular mortality, disease (CVD) events, microvascular disease. We then conducted proportional hazards analysis this post hoc study determine risks type 2 diabetes its complications ‘1hPG‐normal’ group (1hPG <8.6 mmol/L) ‘1hPG‐high’ (≥8.6 mmol/L). predictive values 1hPG 2hPG evaluated using time‐dependent receiver‐operating characteristic (ROC) curve. Results Compared with 1hPG‐normal group, 1hPG‐high had increased (hazard ratio [HR] 4.45, 95% CI 3.43–5.79), mortality (HR 1.46, 1.07–2.01), CVD 1.84, 1.16–2.95), events 1.39, 1.03–1.86) 1.70, CI: 1.03–2.79) after adjusting confounders. exhibited higher area under ROC curve (AUC) predicting than during long‐term (AUC [1hPG vs. 2hPG]: 10 years: 0.86 0.84, p = 0.08; 20 0.88 0.87, 0.04; 30 0.85 0.82, 0.009). Conclusions Elevated level was associated complications, could considered as suitable