Two novel polymorphisms inPLCE1are associated with the susceptibility to esophageal squamous cell carcinoma in Chinese population

• DOI: 10.1111/dote.12463
• Publication Date: 2016-04-10T13:44:19Z
• Authors: Y. Qu; S. Zhang; L. Cui; K. Wang; C. Song; P. Wang; J. Zhang; L. Dai
• Keywords: Genome-wide Association Study

Esophageal cancer is the sixth leading cause of cancer-associated death worldwide. Phospholipase C epsilon 1 (PLCE1) gene was found to be associated with risk esophageal squamous cell carcinoma (ESCC) by three large-scale genome-wide association studies (GWAS) in Chinese populations. To evaluate between single nucleotide polymorphisms (SNPs) PLCE1 and ESCC risk, a case-control study including 550 patients age, gender-matched controls carried out investigate genetic susceptibility SNPs (rs3765524 C/T two unreported potentially functional rs10882379 G/A rs829232 G/A) as well interactions gene-gene gene-environment development ESCC. And results showed that GA genotype significantly reduced compared GG (adjusted OR [95% CI]: 0.66 [0.51, 0.86]), while AA increased 1.37 [1.12, 1.67]). The haplotype analysis Grs10882379Crs3765524Ars829232 Grs10882379Trs3765524Ars829232 haplotypes (95% CI) 1.40 (1.13, 1.73) 1.66 (1.18, 2.34), respectively inversely Ars10882379Crs3765524Grs829232 0.74 (0.61, 0.91). interaction emerged best model consisted four factors (rs10882379, rs3765524, family history ESCC) could increase 'high group' 4.45-fold (OR 5.45 [4.13, 7.19]), 'low group.' Our further validate may contribute Han population. Also play certain crucial role progression.