Effect of neoadjuvant chemoradiotherapy on perioperative immune function of patients with locally advanced esophageal cancer

• DOI: 10.1111/dote.12486
• Publication Date: 2016-10-21T08:36:46Z
• Authors: Jun-Tao Tan; Yang Yang; Nai-Qun Mao; De-Sen Liu; Ding-Ming Huang; Hong Pan; Tong Xie; Qi Pan; Li Yang; Jian-Hong Zhong; Chuan-Tian Zuo
• Keywords: Chemoradiotherapy; Neoadjuvant Therapy

This study aims to evaluate the effect of neoadjuvant chemoradiotherapy (NCRT) on perioperative immune function during surgery treat resectable locally advanced esophageal cancer. Records were retrospectively analyzed for 220 patients with cancer, whom 112 received alone and 98 NCRT plus surgery. The two groups compared in terms proportions CD3+, CD4+, CD8+, natural kill (NK) cells, as well ratio CD4+ CD8+ cells. These measurements made using flow cytometry preoperative day 1 postoperative days 7. Subgroup analysis performed degrees pathological response NCRT. When entire no-NCRT (surgery alone) cohorts compared, no significant differences propocrtions or NK cells CD4+/CD8+ occurred at any three time points. Similar results obtained subgroup who NCRT-sensitive, but NCRT-insensitive showed significantly lower than group. Our findings suggest that does not affect are it reduce such NCRT-insensitive.