Effect of ethanolic extract of Melia dubia leaves on full‐thickness cutaneous wounds in Wistar rats

• DOI: 10.1111/dth.13077
• Publication Date: 2019-08-28T01:33:38Z
• Authors: Ponrasu Thangavel; Pratima Pathak; Iyappan Kuttalam; Suguna Lonchin
• Keywords: Granulation tissue

In recent years, the therapeutic effects of phyto-principles have been appreciated for their promising on wound healing. Melia dubia (Malabar neem) possesses anti-cancer, anti-diabetic, anti-tumor, anti-inflammatory, antioxidant, antibacterial, and fungicidal properties. Here, we studied healing efficacy ethanolic extract M. leaves cutaneous first time. The was applied topically wounds experimental rats until heal completely. Wounds control were treated with PBS. Granulation tissues formed surfaces excision harvested days 4 8 analyzed to determine total collagen hexosamine content. Total significantly (p < .001) higher in compared control. rate closure period epithelialization shorter rats. Incision tissue used tensile strength measurement. Tensile improved tissues. Results concluded that topical application extracts contraction by increased synthesis collagen.