Localized sebaceous carcinoma treatment: Wide local excision verses Mohs micrographic surgery

• DOI: 10.1111/dth.13991
• Publication Date: 2020-07-09T16:28:15Z
• Authors: Marcus L. Elias; Steven R. Skula; Sara Behbahani; W. Clark Lambert; Robert A. Schwartz
• Keywords: Mohs surgery; Wide local excision; Neck dissection; Sebaceous carcinoma

The optimal surgical management of sebaceous carcinoma (SC) has yet to be determined between Mohs micrographic surgery (MMS) and wide local excision (WLE). To investigate overall survival (OS) differences for SC undergoing WLE or MMS, National Cancer Database (NCDB) was queried all from 2004 2015 (n = 2863). Cases missing staging data, palliative care, showing lymph node extension, AJCC Stage III/IV were omitted. Chi-squared tests used analyze patient demographics, cancer characteristics, treatment modalities. Kaplan-Meier Cox proportional hazards regression modeling analyzed OS outcomes. A total 554 cases met inclusion criteria (WLE [n 243], MMS 311]). Multivariate analysis revealed that treated in academic facilities (ref: non-acad; OR 2.273; CI95% [1.448-3.568]; P < .001] independently associated with greater rates, whereas those primaries on the trunk head/neck 0.359; CI95%[0.203-0.634]; .001) extremities 0.399; [0.182-0.877]; .022) held lower rates. Between modalities, showed no significant difference outcomes (P .611), demonstrating 5-year rates 65.8% 61.4%, respectively. On hazard regression, did not show any (HR 0.832; [0.996-3.662]; .334). localized demonstrate similar may preferred margin control, tissue conservation, cosmesis.