Feasibility of an exercise programme in elderly patients undergoing allogeneic stem cell transplantation – a pilot study

• DOI: 10.1111/ecc.12400
• Publication Date: 2015-11-03T05:30:52Z
• Authors: M.K. Schuler; B. Hornemann; C. Pawandenat; M. Kramer; L. Hentschel; H. Beck; P. Kasten; S. Singer; M. Schaich; G. Ehninger; U. Platzbecker; J. Schetelig; M. Bornhäuser
• Keywords: Male; Hematopoietic Stem Cell Transplantation; Pilot Projects; Middle Aged; Exercise Therapy; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Hematologic Neoplasms; Quality of Life; Feasibility Studies; Humans; Patient Compliance; Transplantation, Homologous; Female; Muscle Strength; Prospective Studies; Muscle, Skeletal; Aged

It has been demonstrated that physical exercise benefits younger patients undergoing allogeneic haematopoietic stem cell transplantation (allo-HSCT). We designed a prospective pilot study investigating whether elderly (>60 years) would also be able to participate in such programme. consisted of physiotherapist-supervised alternating endurance and resistance workouts on 6 7 days week. Sixteen consecutive allo-HSCT were enrolled into the study. The median age was 64.5 years. Twelve participated programme until time discharge (75%) from transplant unit. Therefore, predefined criteria regarding feasibility met. reason for drop out associated mortality all (n = 4). Adherence very good with 85% attended training sessions. No adverse events recorded. capacity dropped by 7% lower extremity strength improved 2% over time. Quality life decreased during period, global health being significantly worse at discharge. In conclusion, combined intensified is feasible safe population allo-HSCT. Further research should focus exploring effect sizes an intervention conducting randomised controlled trials.