Feasibility of an exercise programme in elderly patients undergoing allogeneic stem cell transplantation – a pilot study
Male
Hematopoietic Stem Cell Transplantation
Pilot Projects
Middle Aged
Exercise Therapy
3. Good health
03 medical and health sciences
0302 clinical medicine
Hematologic Neoplasms
Quality of Life
Feasibility Studies
Humans
Patient Compliance
Transplantation, Homologous
Female
Muscle Strength
Prospective Studies
Muscle, Skeletal
Aged
DOI:
10.1111/ecc.12400
Publication Date:
2015-11-03T05:30:52Z
AUTHORS (13)
ABSTRACT
It has been demonstrated that physical exercise benefits younger patients undergoing allogeneic haematopoietic stem cell transplantation (allo‐HSCT). We designed a prospective pilot study investigating whether elderly patients (>60 years) would also be able to participate in such a programme. It consisted of physiotherapist‐supervised alternating endurance and resistance workouts on 6 of 7 days a week. Sixteen consecutive patients undergoing allo‐HSCT were enrolled into the study. The median age was 64.5 years. Twelve patients participated in the programme until the time of discharge (75%) from the transplant unit. Therefore, the predefined criteria regarding feasibility were met. The reason for drop out was transplantation associated mortality in all patients (n = 4). Adherence was very good with a median of 85% attended training sessions. No adverse events were recorded. The endurance capacity dropped by 7% and lower extremity strength improved by 2% over time. Quality of life decreased during the study period, with global health being significantly worse at the time of discharge. In conclusion, a combined and intensified strength and endurance exercise programme is feasible and safe in a population of elderly patients undergoing allo‐HSCT. Further research should focus on exploring effect sizes of such an intervention by conducting randomised controlled trials.
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