Feasibility of an exercise programme in elderly patients undergoing allogeneic stem cell transplantation – a pilot study

• DOI: 10.1111/ecc.12400
• Publication Date: 2015-11-03T05:30:52Z
• Authors: M.K. Schuler; B. Hornemann; C. Pawandenat; M. Kramer; L. Hentschel; H. Beck; P. Kasten; S. Singer; M. Schaich; G. Ehninger; U. Platzbecker; J. Schetelig; M. Bornhäuser
• Keywords: Male; Hematopoietic Stem Cell Transplantation; Pilot Projects; Middle Aged; Exercise Therapy; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Hematologic Neoplasms; Quality of Life; Feasibility Studies; Humans; Patient Compliance; Transplantation, Homologous; Female; Muscle Strength; Prospective Studies; Muscle, Skeletal; Aged

It has been demonstrated that physical exercise benefits younger patients undergoing allogeneic haematopoietic stem cell transplantation (allo‐HSCT). We designed a prospective pilot study investigating whether elderly patients (>60 years) would also be able to participate in such a programme. It consisted of physiotherapist‐supervised alternating endurance and resistance workouts on 6 of 7 days a week. Sixteen consecutive patients undergoing allo‐HSCT were enrolled into the study. The median age was 64.5 years. Twelve patients participated in the programme until the time of discharge (75%) from the transplant unit. Therefore, the predefined criteria regarding feasibility were met. The reason for drop out was transplantation associated mortality in all patients (n = 4). Adherence was very good with a median of 85% attended training sessions. No adverse events were recorded. The endurance capacity dropped by 7% and lower extremity strength improved by 2% over time. Quality of life decreased during the study period, with global health being significantly worse at the time of discharge. In conclusion, a combined and intensified strength and endurance exercise programme is feasible and safe in a population of elderly patients undergoing allo‐HSCT. Further research should focus on exploring effect sizes of such an intervention by conducting randomised controlled trials.