Improved detection of myocardial damage in sarcoidosis using longitudinal strain in patients with preserved left ventricular ejection fraction

• DOI: 10.1111/echo.13281
• Publication Date: 2016-09-28T04:18:06Z
• Authors: Gillian Murtagh; Luke J. Laffin; Kershaw V. Patel; Amit V. Patel; Catherine A. Bonham; Zoe Yu; Karima Addetia; Nadia El‐Hangouche; Francesco Maffesanti; Victor Mor‐Avi; D. Kyle Hogarth; Nadera J. Sweiss; John F. Beshai; Roberto M. Lang; Amit R. Patel
• Keywords: Cardiac magnetic resonance; Cardiac sarcoidosis; Speckle tracking echocardiography

Background Cardiac infiltration is an important cause of death in sarcoidosis. Transthoracic echocardiography ( TTE ) has limited sensitivity for the detection cardiac sarcoidosis CS ). Late gadolinium enhancement LGE cardiovascular magnetic resonance CMR used to diagnose but limitations cost and availability. We sought determine whether ‐derived global longitudinal strain GLS may be identify individuals with , despite preserved left ventricular ejection fraction LVEF ), abnormal associated major events MCE Methods studied 31 patients biopsy‐proven extra‐cardiac sarcoidosis, >50% on + group), without − matched by age, sex, severity lung disease. was measured using vendor‐independent speckle tracking software. Parameters right systolic diastolic function were also studied. Receiver‐operating characteristic curves cutoff detection, Kaplan–Meier plots ability predict . Results reduced (−19.6±1.9% vs −14.7±2.4% +, P <.01) E/A ratio (1.1±0.3 0.9±0.3, respectively, =.01). No differences noted other parameters. magnitude inversely correlated burden r =−.59). −17% showed specificity 94% detecting Patients who experienced had worse than those did not (−13.4±0.9% −17.7±0.4%, =.0003). Conclusions significantly presence measurements become part study performed screen