Long‐term prognostic impact of subclinical myocardial dysfunction in patients recovered from COVID‐19

• DOI: 10.1111/echo.15575
• Publication Date: 2023-04-27T01:59:20Z
• Authors: Francesco Cannata; Giuseppe Pinto; Mauro Chiarito; Matteo Maurina; Francesco Condello; Sara Bombace; Alessandro Villaschi; Laura Novelli; Kamil Stankowski; Gaetano Liccardo; Gaia Gasparini; Dario Donia; Anastasia Celata; Ilaria My; Marinos Kallikourdis; Stefano Figliozzi; Riccardo Mantovani; Fabio Fazzari; Renato M. Bragato; Gianluigi Condorelli; Giulio G. Stefanini
• Keywords: Subclinical infection; Mace

Cardiovascular sequelae may occur in patients recovered from coronavirus disease 2019 (COVID-19). Recent studies have detected a considerable incidence of subclinical myocardial dysfunction-assessed with speckle-tracking echocardiography-and long-COVID symptoms these patients. This study aimed to define the long-term prognostic role dysfunction and condition COVID-19 pneumonia.We prospectively followed up 110 hospitalized at our institution due pneumonia April 2020 then SARS-CoV-2 infection. A 7-month clinical echocardiographic evaluation was performed, by 21-month follow-up. The primary outcome major adverse cardiovascular events (MACE), composite infarction, stroke, heart failure hospitalization, all-cause mortality.A dysfunction-defined as an impairment left ventricular global longitudinal strain (≥-18%)-was identified follow-up 37 (34%), associated increased risk MACE good discriminative power (area under curve: .73) resulted strong independent predictor extended multivariate regression analyses. Long-COVID not worse prognosis, instead.In pneumonia, is present one-third whole population higher Speckle-tracking echocardiography promising tool optimize risk-stratification while definition has no relevance.