Longitudinal Trajectory of Left Ventricular Systolic Function in Children During Anthracycline‐Based Chemotherapy Assessed by Noninvasive Myocardial Work

• DOI: 10.1111/echo.70151
• Publication Date: 2025-04-07T17:50:31Z
• Authors: Shanshan Li; Yanxiang Wu; Jingya Li; Yawen Deng; Liyuan Xu; Jiao Yang; Ruijuan Su; Ning Ma
• Keywords: Cardiotoxicity; Systole

ABSTRACT Background Noninvasive myocardial work (MW), which incorporates deformation and blood pressure, can be used to quantitatively evaluate left ventricular (LV) systolic function in children undergoing chemotherapy. However, the trajectories of MW indices (MWIs) during anthracycline‐based chemotherapy remain unclear. Objective To investigate longitudinal MWIs compare relative changes between conventional echocardiographic parameters. Methods Results We retrospectively analyzed 441 echocardiograms from 102 (median age, 7 years; 72 boys) with cancer who received treatment. Conventional parameters (LV ejection fraction [LVEF] global strain [GLS]) (global index [GWI], constructive [GCW], efficiency [GWE], wasted [GWW]) were obtained using GE EchoPAC software. The Mantel–Haenszel Chi‐squared test revealed that GLS, GWI, GCW, GWE all worsened (all p < 0.05 for trend), this deterioration appearing when cumulative dose anthracyclines reached 30–60 mg/m 2 . no significant trends observed LVEF GWW (both > trend). linear mixed models indicated GLS exhibited a consistent downward trend, whereas GWI GCW experienced plateau phase within anthracycline range 100–250 greater than those throughout Conclusion Echocardiographic could provide more sensitive assessment anthracycline‐induced cardiotoxicity (AIC) children, allowing timely adjustment or cardioprotective measures prevent cardiac dysfunction.