Changes in adiponectin level and fat distribution in patients with type 2 diabetes

• DOI: 10.1111/eci.12207
• Publication Date: 2013-11-20T05:26:52Z
• Authors: Tomasz Miazgowski; Joanna Dziwura‐Og...; Krzysztof Safranow; Katarzyna Iskierska; Krystyna Widecka
• Keywords: Blood Glucose; Glycated Hemoglobin; Metabolic Syndrome; Body Weight; Middle Aged; Metformin; Diet; 3. Good health; Postmenopause; 03 medical and health sciences; 0302 clinical medicine; Adipose Tissue; Diabetes Mellitus, Type 2; Body Fat Distribution; Humans; Hypoglycemic Agents; Female; Adiponectin; Prospective Studies; Waist Circumference; Aged

The aim of this study was to assess the impact standard hypoglycaemic treatment strategies on adiponectin levels and fat distribution in patients with newly diagnosed type 2 diabetes mellitus (T2DM).This a prospective observational 50 women T2DM, aged 64·6 ± 7·9 years treated for 12 months lifestyle modification alone (n = 24) or combination metformin 26), according current standards diabetic care clinical practice guidelines. None required insulin therapy during entire period. Total (BF), abdominal (android) hip (gynoid) were measured by dual-energy X-ray absorptiometry at baseline after treatment. adiponectin, glycated haemoglobin (HbA1c) fasting glucose 3-month intervals.Baseline level low (9·37 2·81 μg/mL). Lifestyle modifications produced comparable changes levels, which not associated BF, HbA1c, regional depots. Baseline inversely correlated triglycerides (R -0·441; P 0·0007) android/gynoid ratio -0·272; 0·042). Treatment significant weight reduction (P 0·033), resulted from decrease BF% 0·044) but android gynoid depots.In postmenopausal combined levels. Weight %BF