Cytokine responses, microbial aetiology and short‐term outcome in community‐acquired pneumonia

• DOI: 10.1111/eci.12865
• Publication Date: 2017-11-24T16:16:50Z
• Authors: William W. Siljan; Jan C. Holter; Ståle H. Nymo; Einar Husebye; Thor Ueland; Pål Aukrust; Tom E. Mollnes; Lars Heggelund
• Keywords: Etiology

Abstract Background The inflammatory response to community‐acquired pneumonia ( CAP ) is orchestrated through activation of cytokine networks and the complement system. We examined association multiple cytokines terminal complex TCC with microbial aetiology, disease severity short‐term outcome. Materials methods Plasma levels 27 were analysed in blood samples obtained at hospital admission, clinical stabilization 6‐week follow‐up from 247 hospitalized adults . Fourteen mediators included final analyses. Adverse outcome was defined as intensive care unit ICU admission 30‐day mortality. Results Cytokine dynamic course , highest seen for most mediators. Admission did not differ between groups aetiology. High IL ‐6 (odds ratio [ OR ] 1.47, 95% confidence interval CI 1.18‐1.84, P = .001), ‐8 1.79, 1.26‐2.55, .001) MIP ‐1β 2.28, 1.36‐3.81, .002) associated a CURB ‐65 score ≥3, while 1.37, 1.07‐1.74, .011) 1.86, 1.03‐3.36, .040) high risk an adverse Conclusions In this cohort, ‐6, and/or Still, mediators, only nonsignificant variations responses observed