Relapse in schizophrenia: The role of factors other than non‐adherence to treatment

• DOI: 10.1111/eip.13510
• Publication Date: 2024-02-07T06:39:12Z
• Authors: R. Smit; H. K. Luckhoff; L. Phahladira; S. Du Plessis; R. Emsley; L. Asmal
• Keywords: Relapse prevention

Abstract Aim Relapse rates are very high in schizophrenia. However, little is known about the predictors of time to relapse other than treatment non‐adherence. We investigated possible risk factors for patients with first‐episode schizophrenia ( n = 107) who received assured by way long‐acting injectable antipsychotic over 24 months and underwent regular clinical, cognitive, metabolic assessments. Methods Using Cox regression analyses we assessed selected premorbid baseline potential relapse. was defined using operationally criteria. Results In primary analysis only neurological soft signs total score retained significance, higher scores predicting shorter (HR 1.05, 95% CI 1.01–1.10, p .029). a more detailed secondary poorer social relationships predicted 0.85, 0.76–0.95, .003). Conclusion Our predominantly negative findings suggest that many previously implicated mediated non‐adherence rather having direct effect on relapse‐proneness. Neurological signs, perhaps quality life appear play role merit further investigation.