Incidence and prognostic significance of isolated trisomies in adult acute myeloid leukemia: A population‐based study from the Swedish AML registry

• DOI: 10.1111/ejh.12861
• Publication Date: 2017-02-02T15:36:21Z
• Authors: Vladimir Lj Lazar...; Aldana Rosso; Gunnar Juliusson; Petar Antunovic; Åsa Rangert Derolf; Stefan Deneberg; Lars Möllgård; Bertil Uggla; Lovisa Wennström; Anders Wahlin; Martin Höglund; Sören Lehmann; Bertil Johansson
• Keywords: Trisomy

Abstract Objectives and Methods To ascertain the incidence/clinical implications of isolated autosomal trisomies in adult acute myeloid leukemia (AML), all such cases were retrieved from Swedish AML Registry. Results Of 3179 cytogenetically informative AMLs diagnosed January 1997‐May 2015, 246 (7.7%) had trisomies. The frequency increased by age (2.4% at 18‐60 years vs. 23% >60 years; P <.0001); median was 69 years. five most common +8 (4.0%), +13 (0.9%), +11 (0.8%), +21 (0.7%), +4 (0.5%). Age gender, types treatment, complete remission early death rates did not differ between single trisomy intermediate risk (IR) groups or among with gains chromosomes 4, 8, 11, 13, 21. overall survival (OS) similar (median 1.6 years) IR (1.7 =.251). OS differed frequent trisomies; 2.5 for +4, 1.9 +21, 1.5 +8, 1.1 +11, 0.8 ( =.013). Conclusion trisomies, exception +13, should be grouped as IR.