Risk factors for infections in newly diagnosed Multiple Myeloma patients: A Danish retrospective nationwide cohort study

• DOI: 10.1111/ejh.13190
• Publication Date: 2018-10-29T20:49:43Z
• Authors: Rasmus Sørrig; Tobias W. Klausen; Morten Salomo; Annette Vangsted; Peter Gimsing
• Keywords: Hypogammaglobulinemia

Abstract Objectives Infections pose the greatest risk of early death in patients with Multiple Myeloma. However, few studies have analyzed factors for infections Myeloma patients. The aim this study was to analyze within a population‐based MM cohort. Methods Using Danish registries (from 2005 2013), we all ICD‐10 codes first 6 months diagnosis 2557 Results Pneumonia and sepsis represented 46% infections. Multivariable regression analysis showed that pneumonia were male gender (HR 1.4; P = 0.001), ISS II 1.6; 0.0004) ISSIII 1.8; elevated LDH 2.6; 0.0008). Risk high bone marrow plasma cell % 1.1; 0.038), 1.7; 0.007) III 2.0; 0.002) creatinine 2.1; 0.002). Neither immunoparesis (hypogammaglobulinemia) nor comorbidity significant factors. Conclusions Our suggests tumor burden renal impairment are phase